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AGENDA FOR REGULAR MEETING

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OF THE

TEXAS DEPARTMENT OF CORRECTIONS

IIuntsville, Texas

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TEXAS BOARD OF CORRECTIONS

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HOUSTON, 'fEXAS

March 13, 1967

292nd Meeting

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PROPOSAL FOR STUDIES ON RESPIRATORY VIRAL DISEASE IN NORHAL VOLUNTEERS
InvestIgators:
Dr. Vernon KnIght, M.D.
Dr. Robert Couch. M.D.
Dr. Gordon Douglas. M.D.
Duration of Study:

Departments of Hlcroblology and Medicine
Baylor UnIversity College of MedIcIne
Same
Same

Three to seven years.

DuratIon of ThIs Proposal:

One year.

Number of Subjects for This proposal:
Kinds of Subjects:

Approximately 100.

Healthy adult males aged 17 - 40.

Previous Experience:
The above-named Investigators have been performing studies slmllar
to those In the present proposal for the past five years at the National
Institutes of Health, a division of the U.S. PublIc Health Service, In
Bethesda, Maryland. DurIng this tIme a workIng arrangement simIlar to
the one herein proposed exIsted with the Bureau of Federal PrIsons.
Over a period of five years approximately 2,000 federal prisoners were
brought to the Clinical Center of the National Institutes of Health
Where they remained for a period of three to four weeks. Each would
receive Inoculation with a common cold vIrus In this hospItal setting
and be closely followed and examined by several physicians. These
studies have contributed sIgnifIcantly to better understanding of the
common cold and lnfluenza, led to development and alteration of vaccines,
and pointed the way to new approaches to control.
Since the viruses responsible for most of man's respiratory Illnesses
will not Infect animals, it is necessary to study these InfectIons In
human volunteers. The majority of naturally-infected Individuals neither
seek nor need medIcal aid; and, therefore, productIon of common colds
Is necessary for detailed study. PrIsoners constitute nearly Ideal sub!
Jects for this purpose. Detai Is of the selectIon and use of volunteers
In these previous studies is Included In the accompanying report The Use
of Volunteers In Medical Virology. In additIon, selected reprints of
previously conducted studies are also included.