/.
UNIVERSITY

Of PENNSYLVANIA

PHIL-\O£LPHIA 1910-1

Duhring Laboratories
DEPARUIE:"o--r OF DER~IATOlOGV

Uni\'~nity

Hospital

March II, 1966
John E. Bowyer
Isotopes Branch
Division of Materials Licensing
U.S. Atomic Energy Commission
Washington 2.5, D. C.
Re: DML:IB:JEB (70113)
Dear Mr. Bowyer:
1 passionately hope that the enclosed information
will complete my application for renewal of license nwnber
37-9714-1. 1 do want to emphasize once more that the quantities
employed are exceedingly small and that the risks, in my opinion,
have a corresponding size.
1 regret to have caused you so much difficulty.

Sincerely yours,

o~.-/~#4,~
Albert M. Kligman.
Ene.
cc:

Richard E. Cunningham
Chief, Isotopes Branch
Division of Materials Licensing
U.S. Atomic Energy Commission
Washington, D. C. 20545

~.

RfC£IV rO('1
MAR141966-

- -.
UNIVERSITY

of PE;>,rNSYLVA

VIA

PHILADELPHIA 1910-1

Duhring Laboratories
O£PA"TIIE:-:T OF DER"lATOl.OGY

University Hospital

March II, 1966
John E. Bowyer

Isotopes Branch
Division of Materials Licensing
U.S. Atomic Energy Commission
Washington 25, D. C.
Re: DML:IB:JEB (70113)

Dear Mr. Bowyer:
1 passionately hope that the enclosed information
will complete my application for renewal of license nwnber
37-9714-1.1 do want to emphasize once more that the quantities
employed are exceedingly small and that the risks. in my o}Jinion,
have a corresponding size.
1 regret to have caused you so much difficulty.

Sincerely yours,

c:;:~-_/~#~/~
Albert M. Kligman,
Ene.
cc:

Richard E. Cunningham
Chief, Isotopes Branch
Division of MaterIals Licensing
U.S. Atomic Energy Commission
Washington, 0, C. 20545

~.

Rfc£!VrO(
MAR141966-

_.

>

u.s. ATOMIC OIOtGY COlilllllS$lOfll
lilElllCAL AlPIIlOI"f co..MlrTU

APPRAISAL

Address:

2. Coo"ol No.

Holmesburs County Prison

1. Applic&llt:

Torresdale Avenue & Pennypaclt St. 1

Gry: Philadelphia

_

Stale:

4. Name IUld title of trained individtal

,. Type progn.m:

Albert H. Kligman. H. D.

o Private practice.
o PriYaJ:e prarticc in hospital.
I!J

6. Review:

KI
8.

o

Institutional.

7. Previous application control No.(s)

o

firS(.

R~rk

70113 (JlJl)

Second.

on chKkcd items:

A. All radioisotopes 'lnd

UK:S

stated in application.

o C. Tnining and apencoce of
o D. Doug«.) indiatrd.
o E. QiniaJ tec.hn.iques and proccdum outline-d.
~r.

o

F. Type fWicnt uKd (i.e., tcrminal. infants. normal).

o G. Other
9. Action of Subcommittee

fiI

Approve.

OD

Hwn'ln Applications:

o

Disapprovc.

3-28-66
Signa.rure

~-<>,/
d.

.... _ _........ ,...... _ .

P.

~z

_(a&::;;-.;;_..... ..-: ).-.---- - -

1_ _'

u.s.

ATONIC DlVtGY COMMISSIOH

WUllCAL AOVISO'IT (DlIIluna

APPRAISAL
Holmesburg County Pri80n

1. ApplaUnl;

Addr~s;

Torresdale Avenue & Pennypack St.

Nun~ ~nd tHl~

70113 (JEll)

1--------------------3. Department of Hedicine

City: Philadelphia
4.

2. <Aouol No.

S[at~:

,. Type program:

of framed mdlvldual

Albert H. Xlig=an. H. D.

o
o

PriYJJ~ pra.ctic:~.
Privat:~

practice in hospital.

!] ltutitutional.
6.

R~vIC'W

Kl

7. Previous applicatioo control No.(s)

8. Renu.rx on

o

o

First.

ch~dced

Second.
Items:

A. All UdlOllOlOpeS &rid usn su.ted in application.

[!l 8.

o C. TUlnmg and
o O.
o E. GiniCl1

experlenc:~

of

UKr.

[)OS1~(S) indiC1L~d.
tKhniqu~s

o

F. Type

pat.~nt

used

&nd

proc~dur~

outlined.

(i.~ .• t~rmiQ~1, Inf~nts,

normal).

o G. Other
9. Action of SUOCOR\ln1Uec on Human AppliotlOns:

I7l

Appron.

o

Dis.approve.

~9
....-

,> -

-·1

'./
"
;/.
J/2Y/oo

Signatun .
..... _

_.

1_ _

u.s.

ATOMIC 0I0lGY CO."USSIClfil

NmcAL 1 0 _ Cl:MIIIIlTTU

APPRAISAL
=-s

Address:

2. Coo".1 No.

Holme.burg County Prison

1. Appliunt:

Torresdale Avenue & Pennypack St.

Gry: Philadelphia

70113 (JEll)

1---------------------3. ~ut.ment of Medicine

Srare:

4. Name and title of rrained IndIvidual

,. Type program:

Albert K. Kligman. K. O.

o Private practice.
D

Private pr:artice in bospibl.

~

Instirur..ional.

7. Previous appliatioo coattol No. (s)

Kl

o S«ond.

Fim.

B. Remark on checked items:

o

A. All udiol50tOpn and

~

8.

o

C. Tuining and exptnmce of wer.

o
o

u~

sUted in application.

D. Oonge(s) indicatcd.
E. OiniaJ techniqucs and procedures outlined.

o F. Type patient wed (i.e., terminal. Infants. normal).
o G. Other
9. Action of

o

Subcomnuu~ on

Approve.

Rc.muks:

HWD&t.I Applictions:

o

Diupprove.

Thank you.

4-22-66

Sign&t\l.tc. . ...

.....E.
-

1011.01 . '.......11
••f. _ _ • _ _. . . . _

_-_
__I

R!C:!J\PD
_.. ::I:-IG. :·l.D./rr;:d
.._ _.. _
t~."

_.. _._--

""=)

u.s. llTO'Ut OIU~Y COIlMrs5'OH
WIEDCAl. AO'tS)Ir( !»M"InQ:

APPRAISAL

Address:

2. Coouol No.

Holme.burg County Pri.on

1. Applic.am:

70113 (JEB)

Torre.d.ale Avenue 6. Pennypack St.

Gty, Philadelphia

l. Oeputment of Medicine

St.ate:

s. Type progn.m:

4. Name :lnd title of trained individua..l

Albert M. Klisman. K. D.

o Priv.ate prsctice.
o

Ponte pr&Ctice in bospiul

!J In.stitution.aJ.
6. Review:

tll

First.

7. Previous applic.ation control No.(s)

o Second.

8. Remark 00 check:ed items:

o A. All r.adioisotopn .and

U$d

stated. in applic.ation.

...

...aJ.. .

~ B. UK of ... g~ll~~~'.i.~ ~t~~J~el:}~JI!';'3!~f'~~~fe
for ..5.Cud1..l!•...o.f.. ..ahaar;t.uon...thrQu.&h...tb.e.
Cy.tine an~ Hy4rogen S
th~ 5ine
akin.

a.

o C. Training and cxprrieoce of UKr.
o

D. Dos&S"(') indK=d.

o

E. Oinial techniques and procedures outlined.

o F.
patient used (i.e., termina..l. infants, norm.a1).
o G. Other
Ty~

9. Anion of Subcommittee

o

Approve.

00

Hum.an Appliclions:

o

Disapprove.

Reawb: Approve all but H3 Thymidine.

Don't think

exper.imen~

warrants possibl

hazard.

ti
I

···-·_········~H6·······_··_·_····
lOan 01 .......-.11

Signatun

_

- .•.•_-..

JOhn A. D. Cooper. M.D.
303 East Chicago Avenue
Chicago 1~. Illinoie

j,

""

k..-.-;::..-••- - - - - - - -

u.s.

ATOMIC 0I0tGY COIUftSSUJ"

NI:DICAL AOVI5Cl'n' CD.... fTTE(

APPRAISAL

Addten:

Torresdale Avenue & Pennypack St.

IltJC

Albert H.

1------------------------

SUle:

H. D.

o

Private pn.ctice.

o

Printe practice in bospit1L

!J

Institutional.

7. Previow application control No.(s)

6. Revlcw'

KJ

-

:so Type program:

of tr-a..ned indlvldu.JJ

Kli~n.

70113 (JD)

3. Dcpartmmt of Medicine

Gry: Philadelphia

4. Name and

2. Ceo",,1 No.

Hol.me.sburg County Prhon

Appliunt:

I.

o

Firs!.

S«ond.

8. Renurk on checked Ifems:

o

A. 1\11 radioisocopcs and uSC's stated in appliulion.

~

8. USC'

or ... g~.~~~.~R.l; . ~f~!;J~el1~~.;.3!~t.~.g.~le ...~r.... (or . .5.twlllS...oL.abs.Qrp,t.ion ...thr.ough... t1
Cystine an~ KyArogen

S••

~ym 31ne

sktn.

o C. Tuimng and e.zpeflcncC of user.
o D. Dosagc(s) indicated.
o E. Oinia.1 ttdu:Uques and procedures oullined.
o F. Type patient (i.e.• tctmlnaJ. Infanl,. normal).
o G. Other
~

9. Action of Subcomnunee on Human AppliCJ.tloru:

o

RemuJu:

.

,._

o

App(oY~.

~~.~.r.

Dis.approY~.

3
Approve all excepc H labeled chymidine.
reach che genecic DNA pool.

?!

~~.~6

IOllt 01 .ppo..... H

This macerial, when injecced

/U}'/a..

. . __._ _. 1---

Signatur~. :" : ~: ~E~~E~~.~_~.l_.~.."-I?·

( ...--01

_.._ _._.._-_ .

--...)

u.s.

ATOMIC o.DtGY COMMt$SIOH
MClICAL AlJIIlSOIIrf QlIIIllnu:

APPRAISAL
....... x

Hol.mesburg County Prison

1. AppllClnt:

70113 (JEll)

TorTesdale Avenue 6: Pennypack St. 1

Addr~u:

utJ~

4. Nunc and

Albert M.

_

3. Department of Medicine

Stal~:

City: Philadelphia

6.

2. Coouol No.

of truntd mdlvlduu

,. Type- program:

M. D.

Xli~n.

R~VI~W:

o

Priva1~

pracrice.

o

PriY&t~

practice in hospital.

!J

Institutional.

7. Prnious application coouol No.(s)

o 5«"ond.
8. Runark on

che<:k~d

it~ml:

o A. All n.diolSOC:Opn and
~

USd

IlI.led in lppl.iCllion.

B.

o C. Tr&.lnlng and
o D.
indicated.

a~rienc~ o( IlKr.

OOSlg~(S)

o E. OiniaJ lechniques and
outlined.
o F.
used (Le.• lerminal, Infanls, normu).
o G. Other
proc~durcs

Ty~ pati~nl

,

.., ,

, ••• n

9. Action of Subcommittee on Human Appliatioru:
~ ApptoV~.

Rcmulu:

o

Disapprov~.

Except t~f thymidine. Information show1.ng the labeled cc.pound
remains in the tissue biopsy is essential before I would lpprove
for human use.

5-31-66
_ _ _ _ _...._ _•

_ _I

\

'./
"roMic (HUGT

,._ AEC-J13

IS-.Sll

,-_.
..........._""" ,,-"

CO~UIOH

APPLICATION fOR BYPRODUCT MATERIAL LICENSE

''''0''''''

0,",

II

INSTRUCTIONS._Co_I.,. it __ I
16 if ttl;. "
;,11,1.1 opplicc..l..... If opplu:.,i_ is fo' •_ _.I.f I,eo,,.., c
pl.t. onl., Ir..... I ,hr• ...,h 7 one! ;n".coto ...... ;"forl,..~'ho" or ch_,•• in th. Pf09'.... 01 r.IlI...., •• in h ..... IS tlu• ..,h 1.5•
.... pl._'ol Ill•• t ......... " _. . . ..,,,.It .... 16 "'... sl b. c_pl.t•• 0" ell opplle.'i ..... /oteil , .... _ c0r.'.' '0: U. s.. Atom.c E...
CO"'''''."O'''. W...h':r- 25, D. C. Ano"',oft: It.,op•• Bron,h. 01 .. 1.10" of Lico"'''''' 0'" R-e... o,io"_ UPon opp"..... 1 01

011,1";0100". ,h• • ,1P ICO"' .,11 roc •• ". III" ... ec a.,p,oducl Mot... ol Lie ...... A.. AEC &YfH'oclucr M.'...;ol Lie..... I I i ......
• cc ....l .. o:. w,'" .h. , ......1 ...............,. conto, .... in Titt. 10, Cool. of F.III..... R.....I.'ion •• Port 30 .M ,to.. L,e.'.... '.
roc I I. T,tl. 10, Co';. of F"Mol R.., ... lar,o",. p~ 20.

•

,

,.,

1(l1<M'I. Urr......._

........

~_,MI.

til)

~&rlal ~r.ctor
HoLme.burl County Prt..OD
3Z15 Torre.dale Avenue
PhUad.lphla, Pa. 19136
OVAIlMof.r-l' 10 vst

0......

Sf1.0............CIM'lll'p'l.PS ••. ,

'''''rc .... , f'iiale

WIU If VUO

A",
Phlladelphla, Pa. 19136

,

IY"'~_'U'
...(

....fYOVS UClN$l

N1J""U(S~

{If ... ,

"

........ _

/.,

,_-01

-rm-rtTo""1l'ii.o.tUc..... '37-9714-

•

J'<OlV'OU"l VSfIt{S\

"" • •1 ,....,.,._lr•••_

_. _

••u ....... ..-1,
~

c........... _ ••__.... ,,_, , _
·'Albert M. Kll,rnan. M.D.
_

""._

~

.. .,J ••. . . - _ _,

_n.,... 11"---,
• ,., ""OOUCT
--.-,"-~I

.-

•

_ _ ...... '"- . . . . . 1

3Ss

'Cy.l!De"
ne

Tb,.miclin.

14C

Te8toec.roa•• Cortlcoetariod

•

Chloride •

, ... _

1

u .....

...

0.4 mC •

O. Z mC.

_

rjl~_....., .. -.
OUClIlW "UIPO$l '01 """Ile",
""OOuet
If ....... wlU II USIO
11. _ _......._
... ....
, ... _ ,.,.,., '" • ,eolecr _ . _ ...... _ _., ..4 _
...._.1 ......_

..

...

0.5 mC.

• Cyclotron Producedl lncludad to .bow total radiOlWC.1tcSe

••••11 ... ,....... _

_-"..._..

. . . . . . - . . . ._

- -'- -o-:r.
• m'it:'
•

3H

__" .... _

~

1.1 0tfJ000CAl. .. ...0/01 ""'$ICAl. 'QlIoI ",",0 -.al~ NUMNI 0' MlWCutlU 0' lAC" ~CAl AND Of
I" _1M -",(•.1. .... _ _ '"--.......
IC.&~ 'Ol/llI OlA' IOU _ l "OS$l55 A' ANY 0'" nMl

1.

ZZ:ola

u_ ..........

1LADU,,1ON ... onetJON OHlell (No- . ,
_
...... J _ _ .........

.....

...._

~al ••

•..,..._ II (leo.. """_JIJ./_OI .....

.1 ... ,....,.. •_ _ ..../ ...._.

31la

;?I};:.

1" . . . AEC_JIJ

'-

(5-511

T1tA1NING AND EXPERIENCE OF EACH INDIVIOVAL NAMED IN ITEM ..

t. TYl'f Of T.... INlNG

_'.cl,_

b

'od,_".,,,,,

"'.0...... "'.".

"o"dO,d"O·

...

i

Hat'memanrlJ 6 months
19&3

,od,oltonl

o. 1'""c'Il'I••

I
No

...

I

ho" .,," ",o""o""g '.ch",C1w., ."d .".,

."""'_to

e. Mo .... "'OIlCl .nd (Ole.. I..,on. Ioo"e '. ,,,.,

No

h.

N•

h.

No

.... • "d "'00..... _'" '" ,od,ooc" .. 'y

I
9

(~

N.

~;

No

(h.)

No

Cb)

N.

I

I
I

lUUItNCf WITH ....Ol... TlON
OVlATION Of UI'fI1fNCf

WHUf Ul'1ltt""l W"S CtAlNlO

10 mc

..

..
..
..

.

..

..

..

flow....... _1"1'''''
.. Of
_ ''''UIU''''N'S
-.l _
of

I
SINSJtlYlrt ItANGt

1tA00.. TIQN
OUfCUO

_"I

Inve s tigational

..

2 years

Hahnemann Hospital and
Holmes burg Prison

..
..

WI"'OOW OllCl"'tU

_"'J

........ ,

1-

""9

OS.

__

..

I

IVJ n-=.r,hr.

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-.
100

,

fl ..
1

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..

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1

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.. Sl_rveY1J'\&

.

~

I

..

Coaunerc1a11y available referetaource. ~ .taDdar~. 1A8trum.entll checked alaiD.8t reference source. whenevf
•• d. to d..c.~miJa. c:gaaiacen& 00&1' .

fIlM ....OGf.S. OOsu.o.tlllS, .. NO .IO·... SS .. ' ,-oCtOUtfS OSlO

I""

jij",

bocog...

_.f)- -"",,".1 col...-.., -.d _

......., ., _ . , . - "... /

not indicated
13 '''CIUTttS "''''0 tOIJll'",tNT

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WASTl

'i!x

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........ • _

lj

IN'O.MATIOH 10 _I SUItMITTID ON ADDITIONAL SHilTS
I
,.'
'oc
' . _• ......u
_'
OV••_,
,
111

o..e"lIo

It

be ....II 10. II...........1 ,

1

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,

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_

.,

_,.1 _."

_,

..-

•••

CI.TlflCAII {Ihl. itam m".' b. comp'l.tM by appllco"tl

'.'10 01 ...h .........1IIe. .

W"'.NING._" USC,. S•• hO" 1001
r.p......... "on ....", a.PO'_'" .r 09."e, 01

c""~ ' j , 19,r:·~)1"
~

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•

..

APPLICA liON .0R BYPRODUCT MATERIAL L1CENSE-nlEDICAL

,

1"lell
~

,

.... lTfD STAnS .. rO/lll1( (NEIC.Y COM ..... ISSION

' ..... Afe-)u.

,

SUPPLEMENT .... -Pr.:ECEPTOIl STATEMENT

Th., palil. U 10 b. tompl.ltd by Ih. oppl"onl "h.,,,(lo" I ~lIec.pIO'.
If mOl. 'han onll pncepTor " necenor., 10 doc ...
."perl.nUl, obla'" 0 '.PO.ol. Uolemen' I,om eoch
Bock of page may be uled fa. commen".

•

1'1"""'"

Al'C) .. oo-t$S

Of .....\1( ......

1~""'''I''''

Albert

1..,.'_/1'(_1

CUN!CAt TblNING

AN(>

Pa. 19136

I

->

h'UllN(l Of ..... ~ICl...N ........fD IN 'Hili II ...IOVE

'"

ISOIO"

CONDITIONS Ol.C,NO»O

O~

-

",

c•• *> Olio ••, •••

IU.... UO

IS.. ,

D,og"(HIi of ''''.,rOld funcr,on

1_' J I

•

M. Kligman, M. D., Holmesburg Prison

8215 Torresdale Avenue, Philadelphia

" .,

.
"'.,.,t ,

.ft

h, ...10_'

••

c....

'0'

1.....1.,... , •• _

'0... <'••" .... IS..

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1.,,,t'Io

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f"erllllon
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,

Scann'n; "ud,.,
T,.alm.nl al

h~p.l!hr'a,d'lm

--

T'l!'Olm.nl al e:a,d'ae: e:and,l,on'
T'I!'O'm.n' af Ihr,ald e:a.e:,nama
T.eo'm.n' af palre:rm.mla

P-32
Sal",bl.

,

T'.alm.nl af 1.",k.m'G
T'I!'O'm.nl af bane m.'aualel
T",ma. toc:at"a"on
In',ae:a."lo." ,••olm.nl

,
I
I

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A",-198

Inllae:ov,lo'r ".o,me",

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Se:ann,ng Itvd,.,
C, -,51

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Se:annln9 .tvd •••

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Co-60
Co-60

I
1_I'n I

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I

Inleu'",ol I.ealm.n'
In'.ae:a.. ,la'1' "ea'm.n.

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hl.,he,ollr !teo'menl
CI-137
T,eolm.nl of I",p."f;e:,ol d ...OI., 0' ,h. IOrIO
S. -90
Olt.e. ." < r. ooi .N
Iloropu
C Testoste rone Corticosteroid
u •• boe:k
of l)oge '3 H
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",Not. ,,,'

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Hahnemann Medical College

4

11
6

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-

1963

"I """_'"

-

''''~.''''SiON 0'

30 Hours

....... ' ... 1.._ ......_ .. ,

Formal Course

Ben;aTT'lln Calesnick

37-467-10
1..._

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1-:'. 'J~•

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.

'-- ff)~.J1*d-L> ,

2-

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~r"

Io<tJon

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Note end ""um
,., eonwrution

r.au,.~

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R~umed'

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Phpe,. Repty

for Your l"tOlTl'\ltlOft

k:om""",

Inwsti

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... ...

for Correction

t:lmll~ • . .

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te

Justify

I HOPE EVERYBODY INVOLVED IN THIS
REMEIIBERS THAT THE PURPOSE IS TO CALM
THINGS

DO'~-NOT

STIR THEil UP.

PIIOM: (Hem.. 0f'I. 1",,001. "''''C'1/~t'

TOBY CLARK (TS 788)

D

_1-102

" . . . No.

...

ornoNA1. FDItM 41 (lltev. 7-76)

-"
".... "'I

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IOa-ILaI

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, C.C.

20460

----/
....c:"

o"ner 0" "(SfICloes "NO fOl(lC SU8ST .. NC£S

AUG 14 \98\

-

"-

.

MEMORANDUM
SUBJECT:

Status of Action Plan for Holmesbu

FROI~:

John W. Melone, Acting Director.
Hazard Evaluation Division (T

TO:

Edwin L. Johnson
Deputy Ass'

Offi

t Administrator

of Pesticide Programs (TS-766C)

This memorandum is to serve as an update of our involvement with the
Holmesburg situation.
On May 28, 1981 you req ested that Peter McGrath develop a plan to interview those individuals who were incarcerated in Holmesburg but are now
residing in the Philadelphia area. The intent is to test our hypothesis
that a complete study would not be useful since we cannot identify those
individuals who were in the dioxin studies as opposed to other similar
studies conducted at Holmesburg. On June 9. you instructed Peter to
implement the plan produced by the Health Effects Branch (see attached).
On June 26, letters were sent to approximately 40 individuals who claimed
to have been participants in the dioxin testing. Eighteen individuals
residing in Philadelphia were sent letters which stated they were selected
for the initial interviews. To date. only five individuals of the 18 have
responded, all indicating complete willingness to be interviewed. In an
effort to follow-up on this group. we are attempting to recontact. either
by telephone or letter. those that have not responded. I anticipate this
taking several weeks to complete. We are hoping to conduct the interviews
in Philadelphia the week of August 31, 1981.
The overall situation is further complicated in that some of these individuals are constantly moving from one prison to another, in and out of prison.
and their telephone numbers and resident addresses are frequently changing.
In addition, as time passes "new individuals" contact us claiming that they
were also tested at Holmesburg.
I will keep you alerted to new developments as they occur.
Attachment

)

PROPOSED PLAN AND SCHEDULE FOR HDLHESBURG IDENTIFICATION INTERVIEWS

1/9781

The following proposal for interviewing participants in human testing at
the Holmesburg Prison during the 1960's 1s intended to determine whether
participants in the Dow-Kligman dioxin tests can be identified and whether
such individuals participated 1n other tests (dermal or otherwise) conducted
at that facility. To this end, the following schedule has been developed:
6/1 - 6/5 - Develop and mail letters to all persons who have contacted the Agency to date. claiming possible participation in the Holmesburg dioxin tests. State that
since the time of our letter to them. information has
come to light that raises a question about being able
to identify. with any certainty, participants in the dioxin
tests. Indicate to those in the Philadelphia area that
we need their phone numbers and wish to contact them
further, within several weeks, to attempt to ascertain
their test identity.
Proposed Method of Contact:
Options:

Personal interview in Philadelphia.

Telephone interview; mail questionnaire.

6/8 - 6/19 - Time needed for response from participants now residing in
the Philadelphia area. (This time will also be used to
develop the questionnaire and investigate these respondents.)
6/22 - 1/26 - Make final arrangements (travel, interview appointments, etc.)
for conducting interviews.
6/29 • 7/1

- Drive to Philadelphia and conduct interviews (assuming we
opt for personal i ntervi ews). HEB proposes that i ntervi ews
be conducted simultaneously by Frank Davido and James Boland
from adjoining hotel/motel rooms. Participants would be
responsible for their own transportation.

7/2 - 7/10

- Evaluate data; present brieflng on findings.

·/

ALBERT M. KLIGMAN. M. 0 .• PH. O .
.. O'~'T~L 0"

T"~ U"'IYUlln'

3.' .. ANO

I~"ucr

"!'4IL,t,O[LPHU, •

0" .1:....... Lv .... r...

ITI'I[I[TI
"' ...

O[""'I'ITt04[NT 01" Dl:l'IMATOl.OGY

[Vr. .. c~n .. 2-<IItC

[I<tt"',to" .. S'

November 1, 1965

Richard E. Cunningham, Chief,
Isotopes Branch.
Division of Matenals Licensing
U. S. Atomic Energy Commission
Washington, D. C.
20545

In reo

DML:IB:JEB (70113)

SUBJECT:

Application for ByProduct Material License
Dated July 27, 1965, AND YOUR REQUEST
FOR INFORMATIO DATED September 3, Ie

Dear Mr. Cunningham:
Through an extraordinary series of mischances. my correspondence with you has been exceedingly inadequate. We were originally
in error in not completing the information on Form AEC-313 but the
letter calling this to our attention never reached me. Meanwhile, I have
been blaming Government bureaucracy for "sluggishness l l , It was only
your last letter indicating that this information must be returned within
thirty days which clarifies the difficulties we have had and which finally
reached me yesterday. I beg your pardon and regret the loss of time.
I am submitting the missing information on a duplicate of Form
AEC-3l3 enclosed herewith. I trust that this meets with your approval
and that this application can be processed as soon as possible. Thanking
you ror your courtesy in this matter, 1 am

Very truly yours,

\

•

-

/' "

c.. (' -::

)i~/~~

Albert M. Ktigman, . /D.
Professor of Dermatology

fo.... AEC_J I 3
1'-(1.1

UNITED

~HATU

A'O~IC

,_._....

fNUC;Y COMMISSION

........... _w_

APPLI CATION FOR BYPROOUCT MATERIAL LICENSE

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Albert M. Kligman, M. D.
Medical Director
Holrnesburg County Prison
8215 Torresdale Avenue

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Holmesburg County Prison
Torresdale Ave.
Philadelphia, Pa. 19136

Philadelphia, Pa. 19136

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ual
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This is to amend license H37-9714-

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...""".

M. Kligman. M. D.

Albert

...... U.ItIl
• ., •_·_' __
.'_1

.- - ..._... __--_._------__., -

35 5

Cystme

0.3 mC.

3H

Thymidine

0.5 mC.

l4C

Testosterone, Corticosteriod

22 'a ':'

Chloride

~"ooucr

* Cyclotron
,_.ouc'<u ·u·oou
• '_11 .... .....

u ._ _...

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....

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0.4 mC.

0.2 mC.

*

Produced; included to show total radionuclide usage.

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see 313a

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T1lAINING AND [XPElllfNCE Of

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I~--"u"-s.,,,ed to _de~~ rmine cons is ten t .,Joe ra t,io""n~.____,____,__,---------_:___,__,--I' , ....... ocu DOS'Ml!TfU. ANO 110 "UA' ,.-oaou.u vuo
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..........._ _ 31-

APPUCAnON FOR BYPRODUCT MAnRIAl UCENSf

'oG. I

SUPPlfMfNT A-HUMAN USE

If b)'p.oduCl _ _ '101 " 10' human UM . (,nil mol Od"""",,OhOl'I of byp'od",cl "",0""01, 0' "'- lodlOt.Ofl th.,On-O", 10 "'",mO" b.,,,
compl",o !till ,,,,pplemon' Qnd ottoc:h to tho OpphCOhon fo. byproduct ma'-<'IQII'u·I'IM.

,

l_1 USING ""'SICI""'.5

101 ,.......- .......0 AOOIUS 0' """llC..t.HT I" • ___ ..... 'I_II

,.~

-- -

Albert M. Kligman, M. D.

,
,

1'101 U~I'OG ,,""K:~ .. lNO'CAnO .60Vf IS UCI""~O fa DlVtNU OIUCS ,... T'* NACtlCt Of """0lCJN( I f A ST,U! 01 nnlfOl'T
Of ""( u....-rfD su.us ti'llf DlSTItlO Of (OI.u_" 01 T'I4f CO-e..rwWh' Of "",no IICO

@I

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0' ,,"II Al'I'lICAIION
I' ,,"''sWU IS !:!Q.. uSf h(,.f , Of THIS SlWf'\f""NT 10 (U\AlN 01 Iffll TO Olttf. """"UCATIOH 0'(LAttO OOCU .......'U ON WMIOt THIS lNfO.......... OQlo.I

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a.

"OPOSfO DIA.GNOSIS 01 TlfA,rMlt-IT

•

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(v.. ..... 1 ..............

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1"1 Qof,wUl,

,..

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see item 6b, Fonn 313
on(llIII! "OClOl.MU ...."1(.. WIU ., OIUtVlO 10 M1 ....,wl( toALUO'lIO/o<I M......cJUHO. STOIAG': •

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'"' IY..covaI_fltlAL,

See appendix
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(II ",nACMIIO IUTU,ATV_ ItlPlIlNCU WlU ~U"l(fl
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5
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l'lC, Testoste rone. Cortlcosteriod - 2. to 5 microcuries, applied topically
22Na' ChlorIde - 5 to 10 microcuries. injected intradermally
Cyclotron produced; lncluded lO show total radio nuclide usage.
See. also, appendi~
.... _

,

_

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CJtCI' ANSWH

HOS'fTAl fACIlITIES fOIINOIV!DUAl

Q

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..

APPliCATION FOR BYPRODUCT MATIRIAL UCENSE

/10.011
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_..
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.... ) f

SUPl'lEMENT ...-HUMAN USE

0'

Thil pog. may b. eample-.d by"'" p!olylte:torI·, pr.e.plat (,f anyl ill "'" medical u"
.odia,.afape:,. W".n the ,n'o"",ahOl'l "
",,'I1I,".d by t+t. p••e.p.... ,.,. _ .... ona pr".,.,1 addr... of ItI. ptec.plar Ilf any) '''ould b. ,hawII In 'I.... 12 b.low.

M.D.

Albert M. Kligman. Ph. D.

Albert M. Kligman, M.D.

10. ClINCAl TUtNING ANO UI'UlfNCf Of PHYSICIAN WHO WfU ust I't'f'lOOUCT _fUtAl

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July 8. 1965

Albert M. Kligman, M. D.

Application for Byproduct Material License

Appendix

For

tTl

313, Item 13, Facl1itles and Equipment:

The laboratory is a remodelled prison cell containing workbases
and laboratory tables. Lead or steel shielding is available for storage of
the gamma emitting 22Na.
Tongs and pipetting devices are available. Lab. coats and rubber
gloves will be used. Work is performed over trays.
For m

313, Item 14, Radiation Protection Program:

The Holmesburg County Prison established a Medical Isotope
Committee in 1963. This Committee reviews and passes upon any project
utIlizing radionuclides for research and/or in humans. The present membership is:
Albe rt M. Kligman, Ph. D., M. D. ,
Professor of Dermatology at the Vniv. of Penna.
(Certified dermatologist)
Herbert W. Copelan. M. D.
ASSistant Professor of Medicine at the Vniv. of Penna.
(Intermst)
The stock radioactivity is stored in closed containers, well
labelled, and with shielding if indicated. Doses are prepared by withdrawing
a few nucrocuries from the bottle by syringe, using sterile technique for
Intradermal administration, and administering in the laboratory. The site
of administration is then covered with a plastic (Saran Wrap) and the subject
returns to duties. Subsequently, measurements are made and subject scrubs
site of application at least twice with soap and water. Potentially contaminated
materials are collected for decontamination or as waste.
Fa rm 313, Item 15, Waste Disposal:
Most material will appear in subject excreta or wash water and
thus to drains. As we will not exceed two to four studies pe r week, sewer

-2 -

July 8, 1965

Albert :v1. Kligman. M. D.

Applicauon for Byproduct Material License

Appendix

Form 3l3.1tem 13. FaC11itlesandEquipment:
The laboratory 15 a remodelled prison cell contalmng workbases
and laboratory tables. Lead or steel shielding is available for storage of
the gamma emitting 22Na.
Tongs and pipetting devices are available. Lab. coats and rubber
gloves WIll be used. Work IS periormed over trays.
For m

313, Item 14. RadiatIon Protection Program:

The Holmesburg County Prison established a Medical Isotope
Committee In 1963. This CommIttee reviews and passes upon any project
utlliz.lng radionuclides tor research and/or in humans. The present membershIp is:
Albert M. Kligman. Ph. D .. M. D.,
Professor of Dermatology at the Univ. of Penna.
(Certified dermatologIst)
Herbert W. Copelan. M. D.
ASSIstant Professor of Medicine at the Univ. of Penna.
(interOlst)
The stock radioactIvity is stored in closed containers. well
labelled, and with shielding if mdicated. Doses are prepared by withdrawing
a few nucrocurtes from the bottle by syringe, using sterile technique for
Intradermal admInlStration. and administering in the laboratory. The site
of admln!stratlon IS then covered with a plastic (Saran Wrap) and the subject
returns to duties. Subsequently. measurements are made and subject scrubs
sIte of applicatIon at least tWIce with soap and water. Potentially contaminated
materials are collected for decontamination or as waste.
Form 313, Item 15. Waste Disposal:
Most material wlll appear in subject excreta or wash water and
thus to draIns. As we wd! not exceed twO to four studies per week. sewer

-2-

-2 -

disposal limits of AEC regulations will not be exceeded. Other items, such
as old stock bottles. etc. will be washed and either kept as solid waste in a
labelled container Or checked with sultable monitor and discorded or re -used.
In tlme. collected solid wastes will be di;;posed of via commercial
service, probably Nuclear Engineering. Inc .. or by transfer to one of the
large scale radionuclide users in the Philadelphia area for such disposal.
Form 313a, Item -la,
The materials will be used to study the absorption through the skin
by topical application or intradermal injectlon. Studies are performed in
volunteers comprising normal adult males and subjects with pathological
skin conditions (also adult males). Subjects will be volunteers (prisoners).
The nature of the study will be explained to them. Maximum doses are given
in For m 313a, Item Sa. Rarely, up to twO repeat studies may be made in
the subject separated by at least two weeks.
These studies and the techmques are the same as described In
literature references as follow:
Malkinson, F. D.,
Studies on the Percutaneous Absorption of
C 1-4 labelled steroids by use ot' the gas flow cell. ,
J. Invest. Derm. 31:19, 1958

•

Levan, N. E. et ai, Biphasic changes
now afte r U. V. radiation.
J. Invest. Derm. 43:451, 1964

In

cutaneous enective blood

The most instances. over half of the material is absorbed rapidly
and excreted in from one to two days. 3H Thymidine absorbed will largely
go to proliferating cells in the vicinity of the site of application. Some of the
material would be expected to slough off in dead skin.
Form 313a, Item 6.
By product material will be obtained in pre calibrated and sterHyzed
form.

6/.-;,./A"~;',,~-,~<Albert M. Kligma;?'M. D.